The Neapolitan Mastiff Dog has some specific health problems. The most common is Cherry Eye. Others include:
- Hip dysplasia
- elbow dysplasia
- sebaceous adenitis
- Progressive retinal atrophy
- Skin infections between skin folds called pyoderma
- anesthetic sensitivity
Additionally, Neos do not do well in hot climates, and are subject to heat stroke. Like most giant breeds, the Neapolitan Mastiff is not very long, with an average of 7-9 years, however, with a weight maintenance diet properly functioning correctly biologically safe and appropriate, there is no reason not to say that Neo can live also.
When it comes to exercise, Neapolitans are not a very active breed, as the energy tends to be short-lived and their weight causes stress on the joints when excessive. However, they may have bursts of energy and very powerful.